comparative studies of the chromosomal arrangement in the c-metaphase between normal karyotype and trisomy-21

نویسندگان

e. korn; g. schwanitz

m.p. baur

p. mehdipour

d.d. farhud

چکیده

human chromosomes in amnion cells and lymphocytes with normal karyotype and in lymphocytes with pathological karyotype (2n=47, +21) were compared as to their position in the metaphase. none of the collectives showed sex differences. measurement of the radial distances revealed more peripheral position of the majority of large chromosomes. the satellite-carrying chromosomes of the d group always had a central position in the mitosis. the chromosomes of the groups d, e, f and g were closest to the centre; with the exception of chromosome 18 which was peripheral in all three collectives. for the male probands, the y-chromosome was shown in all three collectives to have a smaller radial distance than the x-chromosome. a typical distribution was found for the radial and homologue distances for the trisomic cells, two of them had a very large radial distance, the third a value corresponding to its size. for the homolarger measurements hereby the distribution is quite independent of parental source. comparison of the groups showed no differences either between normal and trisomy cells or between the different cell types. examination of chromosomes 6 and 15 proved conclusively that the chromosomes are not particularly orientated in the c-metaphase regarding the position of short and long arm. a preferential combination of particular satellite carrying chromosomes leads to the frequent fusions of chromosomes 13 and 14, or 14 and 21. equally, no preferential association could be demonstrated of the chromosome 21 and the chromosomes with large heterochromatin blocks in the centromere region (chromosomes 1 and 9). the distances were of the same order of magnitude as those between 21 and chromosome 6, a submetacentric chromosome without a marked heterochromatin region. both latter observations are of specific importance for genetic councelling of couples after birth of a child with a de novo chromosome aberration asking for the recurrence risk.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

a comparative study of the relationship between self-, peer-, and teacher-assessments in productive skills

تمایل به ارزیابی جایگزین و تعویض آن با آزمون سنتی مداد و کاغذ در سالهای اخیر افزایش یافته است. اکثر زبان آموزان در کلاس های زبان از نمره نهایی که استاد تعیین میکند ناراضی اند. این تحقیق جهت بررسی ارزیابی در کلاس های زبان انگلیسی به هدف رضایتمندی زبان آموزان از نمره هایشان انجام گرفته است که در آن نمرات ارائه شده توسط سه گروه ارزیاب (ارزیابی خود دانشجو، همسالان واستاد) در مهارت های تولید (تکل...

15 صفحه اول

the relationship between learners critical thinking ability and their performance in the reading sections of the tofel and ielts test

the study reflected in this thesis aims at finding out relationships between critical thinking (ct), and the reading sections of tofel and ielts tests. the study tries to find any relationships between the ct ability of students and their performance on reading tests of tofel and academic ielts. however, no research has ever been conducted to investigate the relationship between ct and the read...

15 صفحه اول

the relationship between academic self-concept and academic achievement in english and general subjects of the students of high school

according to research, academic self-concept and academic achievement are mutually interdependent. in the present study, the aim was to determine the relationship between the academic self-concept and the academic achievement of students in english as a foreign language and general subjects. the participants were 320 students studying in 4th grade of high school in three cities of noor, nowshah...

the analysis of the role of the speech acts theory in translating and dubbing hollywood films

از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of public health

جلد ۱۶، شماره ۱-۴، صفحات ۲۵-۵۶

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023